Umsebenzi owaziwayo we-melatonin kukuphucula umgangatho wokulala (i-dosage 0.1 ~ 0.3mg), ukunciphisa ixesha lokuvuka kunye nexesha lokulala ngaphambi kokulala, ukuphucula umgangatho wokulala, ukunciphisa kakhulu inani lokuvuka ngexesha lokulala, ukunciphisa inqanaba lokulala, ukwandisa ixesha elide. inqanaba lokulala olunzulu, kwaye unciphise umda wokuvuka ngentsasa elandelayo.Inomsebenzi oqinileyo wokuhlengahlengisa umahluko wexesha.
Olona phawu lukhulu lwe-melatonin kukuba yeyona nto inamandla endogenous free radical scavenger efunyenweyo ukuza kuthi ga ngoku.Umsebenzi osisiseko we-melatonin kukuthatha inxaxheba kwinkqubo ye-antioxidant kunye nokukhusela iiseli emonakalweni we-oxidative.Kule nkalo, ukusebenza kwayo kudlula zonke izinto ezaziwayo emzimbeni.Uphando olutshanje luye lwabonisa ukuba i-MT ingumphathi-oyintloko we-endocrine, olawula imisebenzi yeengqungquthela ezahlukeneyo ze-endocrine emzimbeni.Inemisebenzi elandelayo:
Ukuthintela utshintsho lwe-pathological
Ngenxa yokuba i-MT ilula ukungena kwiiseli, ingasetyenziselwa ukukhusela iDNA yenyukliya.Ukuba iDNA yonakele, inokukhokelela kumhlaza.
Ukuba kukho iMel eyaneleyo egazini, akukho lula ukufumana umhlaza.
Lungisa isingqisho se-circadian
Ukukhutshwa kwemelatonin kunesingqisho esijikelezayo.Emva kokuhlwa, ukuvuselela ukukhanya kuba buthathaka, umsebenzi we-enzyme ye-melatonin synthesis kwi-pineal gland uyenyuka, kwaye inqanaba lokukhuselwa kwe-melatonin emzimbeni liyenyuka ngokuhambelanayo, ukufikelela kwincopho ye-2-3 am inqanaba le-melatonin ebusuku lichaphazela ngqo umgangatho. yokulala.Ngokukhula kweminyaka, i-pineal gland iyancipha de i-calcification, ibangele ukuba buthathaka okanye ukunyamalala kwesigqi sewotshi yebhayoloji, Ingakumbi emva kweminyaka engama-35 ubudala, inqanaba le-melatonin efihliweyo ngumzimba lehle kakhulu, ngokuncipha okuphakathi kwe-10. -15% yonke iminyaka eyi-10, ekhokelela ekuphazamisekeni kokulala kunye nochungechunge lweengxaki zokusebenza.Ukuncipha kwenqanaba le-melatonin kunye nokulala yenye yeempawu ezibalulekileyo zokuguga kwengqondo yomntu.Ke ngoko, ukongezwa kwe-melatonin kwi-vitro kunokugcina inqanaba le-melatonin emzimbeni kwimeko eselula, ukulungelelanisa nokubuyisela isigqi se-circadian, esingenako ukuqinisa ubuthongo kuphela, kodwa nokuphucula umgangatho wobomi, Ukuphucula umgangatho wokulala, kubaluleke kakhulu ukuphucula imeko yokusebenza komzimba wonke, ukuphucula umgangatho wobomi kunye nokulibazisa inkqubo yokuguga.
I-Melatonin luhlobo lwehomoni olunokubangela ukulala kwendalo.Inokoyisa ukuphazamiseka kokulala kwaye iphucule umgangatho wokulala ngokulawula ubuthongo bendalo.Owona mahluko mkhulu phakathi kwe-melatonin kunye nezinye iipilisi zokulala kukuba i-melatonin ayinakhobo kwaye akukho ziphumo bezingalindelekanga zicacileyo.Ukuthatha i-1-2 tablets (malunga ne-1.5-3mg ye-melatonin) ngaphambi kokulala ebusuku kunokuvelisa ukozela phakathi kwe-20 ukuya kwimizuzu engama-30, kodwa i-melatonin iya kuphelelwa ngamandla emva kokusa kusasa, emva kokuvuka, akuyi kubakho mvakalelo. ukudinwa, ukozela nokungakwazi ukuvuka.
Libazise ukwaluphala
I-pineal gland yabantu abadala iyancipha ngokuthe ngcembe kwaye imfihlo yeMel iyancipha ngokuhambelanayo.Ukunqongophala kweMel efunwa ngamalungu ahlukeneyo emzimbeni kukhokelela ekugugeni nakwizifo.Izazinzulu zilibiza i-pineal gland ngokuthi “iwotshi yokuguga” yomzimba.Songezelela uMel emzimbeni, kwaye ke sinokuyibuyisela umva iwotshi yokuguga.Ekwindla ka-1985, izazinzulu zasebenzisa iigundane zeenyanga ezili-19 (iminyaka engama-65 ubudala ebantwini).Iimeko zokuphila kunye nokutya kweqela A kunye neqela B zazifana ncakasana, ngaphandle kokuba uMel wongezwa kumanzi okusela eqela A ebusuku, kwaye akukho nto yongezwa kumanzi okusela eqela B. Ekuqaleni, kwakungekho nto yayingeyomfuneko. umahluko phakathi kwamaqela amabini.Ngokuthe ngcembe, kwabakho umahluko omangalisayo.Iimpuku ezikwiqela lolawulo B zaziguga ngokucacileyo: ubunzima bezihlunu banyamalala, amabala enkqayi agqume ulusu, idyspepsia kunye necataract emehlweni.Lilonke, iimpuku zeli qela zazindala yaye zisifa.Iyamangalisa into yokuba iqela leempuku ezisela amanzi eMel rhoqo ebusuku zidlala nabazukulwana bazo.Umzimba wonke uneenwele ezishinyeneyo ezishinyeneyo, ezikhazimlayo, zokwetyisa kakuhle, kwaye akukho cataract emehlweni.Ngokubhekiselele kumndilili wobomi bazo, iimpuku ezikwiqela B zonke zabandezeleka kangangeenyanga ezingama-24 (okulingana neminyaka engama-75 ubudala ebantwini);Umndilili wobomi beempuku kwiqela A ziinyanga ezingama-30 (iminyaka eyi-100 yobomi bomntu).
Impembelelo yokulawula kwinkqubo ye-nervous central
Inani elikhulu lezifundo zeklinikhi kunye novavanyo lubonise ukuba i-melatonin, njengehomoni ye-neuroendocrine engapheliyo, inolawulo oluthe ngqo kunye olungathanga ngqo lwe-physiological system kwinkqubo ye-nervous central, inefuthe lonyango ekuphazamisekeni kokulala, ukudakumba kunye nezifo zengqondo, kwaye inefuthe lokukhusela kwiiseli ze-nerve. .Ngokomzekelo, i-melatonin inomphumo wokuthomalalisa, inokunyanga ukudandatheka kunye nengqondo, inokukhusela i-nerve, inokuphelisa intlungu, ilawule ukukhutshwa kwamahomoni kwi-hypothalamus, njalo njalo.
Ukulawulwa kwamajoni omzimba
I-Neuroendocrine kunye ne-immune system zihambelana.I-immune system kunye nemveliso yayo inokutshintsha umsebenzi we-neuroendocrine.Iimpawu ze-Neuroendocrine nazo zichaphazela ukusebenza komzimba.Kwiminyaka elishumi yakutshanje, impembelelo elawulayo ye-melatonin kwinkqubo yomzimba yokuzikhusela iye yatsala ingqalelo ebanzi.Izifundo ekhaya nakwamanye amazwe zibonisa ukuba ayichaphazeli kuphela ukukhula kunye nokuphuhliswa kwamalungu omzimba, kodwa ilawula i-humoral and cellular immune, kunye ne-cytokines.Ngokomzekelo, i-melatonin inokulawula ukugonywa kweselula kunye ne-humoral, kunye nemisebenzi yeentlobo ezahlukeneyo ze-cytokines.
Ukulawulwa kwenkqubo ye-cardiovascular system
I-Mel luhlobo lwesignali yokukhanya enemisebenzi emininzi.Ngokutshintsha kwemfihlo yayo, inokudlulisa ulwazi lomjikelezo wokukhanya kokusingqongileyo kwizicubu ezifanelekileyo emzimbeni, ukwenzela ukuba imisebenzi yabo esebenzayo ikwazi ukulungelelanisa utshintsho lwehlabathi langaphandle.Ke ngoko, inqanaba le-serum melatonin secretion lingabonakalisa ixesha elihambelanayo losuku kunye nexesha elihambelanayo lonyaka.I-circadian kunye nezingqisho zonyaka zezinto eziphilayo zihambelana ngokusondeleyo neenguqu zamaxesha ngamaxesha kunye nokunikezelwa kwe-oksijini ye-cardiovascular system kunye nenkqubo yokuphefumula.Umsebenzi we-vascular system unesingqisho esicacileyo se-circadian kunye nexesha lonyaka, kubandakanywa uxinzelelo lwegazi, izinga lokubetha kwentliziyo, ukuphuma kwentliziyo, i-renin angiotensin aldosterone, njl njl. ukuqala kokuxhomekeka kwixesha.Ukongeza, uxinzelelo lwegazi kunye ne-catecholamine yehla ebusuku.I-Mel ifihliwe kakhulu ebusuku, ichaphazela iindidi ze-endocrine kunye nemisebenzi ye-biological.Ubudlelwane phakathi kweMel kunye nenkqubo ye-circulatory inokuqinisekiswa ngezi ziphumo zovavanyo ezilandelayo: ukwanda kwe-Mel secretion ebusuku kuhambelana kakubi nokuncipha komsebenzi we-cardiovascular;I-Melatonin kwi-pineal gland inokuthintela i-arrhythmia ye-cardiac ebangelwa ukulimala kwe-ischemia-reperfusion, ichaphazela ukulawula uxinzelelo lwegazi, ilawula ukuhamba kwegazi kwi-cerebral, kunye nokulawula impendulo ye-peripheral arteries kwi-norepinephrine.Ngoko ke, uMel unokulawula inkqubo ye-cardiovascular system.
Ukongeza, i-melatonin ilawula inkqubo yokuphefumla, inkqubo yokugaya kunye nenkqubo yomchamo.
Ixesha lokuposa: Jun-22-2021