Imveliso: 2-phenylacetamide
Ifomula yemolekyuli: C8H9NO
Ubunzima bemolekyuli: 135.17
Igama lesiNgesi: Phenylacetamide
Umlinganiswa: Iflake elimhlophe okanye iikristale ezimile okwegqabi.Mp 157-158 ℃, bp 280-290 ℃ (ukubola).Inyibilika emanzini ashushu kunye ne-ethanol, inyibilika kancinane emanzini abandayo, i-ether, kunye nebenzene.
Ukusetyenziswa: Phakathi kweziyobisi ezifana ne-penicillin kunye ne-phenobarbital.Ikwasetyenziselwa ukulungisa i-phenylacetic acid, iziqholo, kunye nezibulali zinambuzane.
Indlela yoku-1) iMasuko F，Katsura T.US 4536599A1.1985.
Yongeza i-117.2 g (1.0 mol) ye-phenylacetonitrile (2), 56.1 g ye-25% yesisombululo se-potassium hydroxide, 291.5 g ye-35% ye-hydrogen peroxide isisombululo samanzi, i-1.78 g ye-benzyltriethylammonium chloride, kunye ne-351.5 g ye-reaction ye-isopropanoGxuma kwaye usabele kwi-50 ℃ iiyure ezi-4.Emva kokuba impendulo igqityiwe, i-isopropanol ikhutshwe phantsi koxinzelelo oluncitshisiweyo, ipholile, ihluzwe, ihlanjwe ngamanzi, kwaye yomiswe ukufumana i-compound (1) 128.5 g, mp 155 ℃, kunye nesivuno se-95%.
Indlela yesi-2) Furniss BS, Hannaford AJ, Rogers V, et al.Incwadi kaVogel ye-Practical Chemistry.Longman London kunye neNew York.Ushicilelo lwesine,1978:518.
Yongeza i-100 g (0.85 mol) ye-phenylacetonitrile (2) kunye ne-400 mL ye-concentrated hydrochloric acid kwi-flask yokusabela.Phantsi kokuxhokonxa, phendula ku-40 ℃ malunga nemizuzu engama-40, kwaye unyuse ubushushu ukuya kuma-50 ℃.Qhubeka usabela imizuzu engama-30.Pholisa ukuya kwi-15 ℃ kwaye wongeze i-400 mL yamanzi abandayo adibeneyo.Ukupholisa kwindawo yokuhlambela amanzi omkhenkce, ukuhluza iikristale.Yongeza okuqinileyo kwi-50 mL yamanzi kwaye ugxobhoze ngokucokisekileyo ukususa i-phenylacetic acid.Hlunga kwaye wome kwi-50-80 ℃ ukufumana i-95 g ye-phenylacetamide (1), mp 154-155 ℃, kunye nesivuno se-82%.Ukuhlaziya kwakhona nge-ethanol, mp 156 ℃.
Ixesha lokuposa: Apr-11-2023