Singomnye wabaphambiliababoneleli nge-n-methylbenzamidekunye nabavelisi eChina, ukuba ufuna ukufumanaumzi-mveliso we-n-methylbenzamide, zive ukhululekile ukuqhagamshelana nathi kwaye usithumele i-imeyile.
1. YintoniN-Methylbenzamide?
I-N-methylbenzamide yi-phosphodiesterase esebenzayo ye-10A (pde10a) inhibitor.I-N-methylbenzamide inomsebenzi we-anticancer.PDE10A yiphosphodiesterase esanda kuchongwa enendawo ephawulekayo yendawo njengoko iprotheni ininzi kuphela kwizicubu zobuchopho.Ngokusekwe kolu luntu lukhethekileyo, uphando lugxile kakhulu ekusebenziseni iimodyuli ze-PDE10A njengendlela entsha yonyango yokungasebenzi kakuhle kwisekethe ye-basal ganglia kubandakanya isifo sika-Parkinson, isifo sika-Huntington, ischizophrenia, umlutha kunye nokuphazamiseka okunyanzelekileyo.Imizamo ye-chemistry yonyango ichonge i-N-methyl-N- [4- (quinolin-2-ylmethoxy) -phenyl] -isonicotinamide njenge-nanomolar PDE10A inhibitor.Inkqubo elandelayo yokuphucula iNkokheli ichongiwe i-N-methylanilides efanayo kunye ne-N-methylbenzamide ehambelana nayo njenge-PDE10A inhibitors enamandla, ngaxeshanye iindlela zokubopha ezinomdla nezingalindelekanga zachongwa.
Indawo yokunyibilika ngama-76-78 ° C
Indawo yokubila yi-167 ° C
Uxinaniso 1.1031
Refractive index 1.5589
Iimeko zokugcina zivaliwe zomile, ubushushu begumbi
I-ethanol yokunyibilika: i-soluble 50mg / ml, ukunyibilika kwamanzi:Akunyibilikiyo emanzini
I-CAS:613-93-4
Imbonakalo: Ikristale emhlophe
2. Isicelo esiphambili
I-inhibitor, i-anticancer, i-organic synthesis ephakathi, iikhemikhali zeelabhoratri
3.Ukugcinwa kunye nokuPakisha
3.Amanyathelo oncedo lokuqala
Ukuqhagamshelana kwamehlo: Sula ngokukhawuleza ngamanzi amaninzi, nangaphantsi kweenkophe, ubuncinane imizuzu eyi-15.Fumana unyango.
Ukuqhagamshelana noLusu: Hlamba kwangoko ngesepha kunye namanzi amaninzi ngelixa ususa zonke iimpahla kunye nezihlangu ezingcolileyo.
Ukuphefumla: Susa ekutyhilekeni, lala phantsi.Susa emoyeni omtsha.Ukuba awuphefumli, nika ukuphefumla okwenziweyo.
Ukuginya: Coca umlomo ngamanzi.Fumana unyango.
Iimpawu ezibalulekileyo kunye nemiphumo: Akukho lwazi lukhoyo.
UkuziKhusela koMncedi wokuqala: Akukho manyathelo okhuseleko afunekayo.
Amanqaku kuGqirha: Nyanga ngeempawu.
4. Ulwazi lwezothutho
UThutho lweNdlela nooLoliwe : aluLawulwa
IMDG/IMO : Ayilawulwa
IATA : Ayilawulwa
Izilumkiso eziKhethekileyo zoMsebenzisi: Akukho zilumkiso zikhethekileyo ezifunekayo
5. HTML5 spectrum
IHebei Guanlang Biotechnology Co., Ltd. yeyaseGuanlang Group, eyasekwa ngonyaka ka-2007, ikwidolophu yaseShijiazhuang eyinkunzi yePhondo leHebei kunye necandelo le-hub phakathi kweBeijing Tianjin kunye neHebei kwaye inenzuzo yokuhamba ngokulula.Inkampani yethu lishishini lemichiza lanamhlanje elinobuchwephesha obuphezulu kunye noPhando kunye noPhuhliso, imveliso kunye nokuthengisa. Sinefektri yethu kunye nelebhu, sikwabonelela ngenkonzo yokudibanisa eyenzelwe abathengi bethu.
