I-1,3-Dihydroxyacetone Iindlela zoMveliso kunye nezicelo zokuqaliswa kwe-CAS 96-26-4

I-1,3-Dihydroxyacetone Isingeniso

I-1,3-Dihydroxyacetone i-organic compound kunye ne-molecular formula C3H6O3, eyi-polyhydroxyketose kunye ne-ketose elula.Imbonakalo yikristale emhlophe engumgubo, enyibilika ngokulula kwizinyibilikisi eziphilayo ezifana namanzi, i-ethanol, i-ether, kunye ne-acetone.Indawo yokunyibilika yi 75-80 ℃, kwaye ukunyibilika kwamanzi yi>250g/L (20 ℃).Inencasa eswiti kwaye izinzile kwi-pH 6.0.I-1,3-Dihydroxyacetone ishukela elinciphisa.Zonke i-monosaccharides (ngokude nje kukho i-aldehyde yamahhala okanye amaqela e-ketone carbonyl) anokunciphisa.I-Dihydroxyacetone ihlangabezana nezi meko zingasentla, ngoko ke iyinxalenye yodidi lokunciphisa iswekile.

Kukho ubukhulu becala iindlela zokudityaniswa kweekhemikhali kunye neendlela zokubilisa iintsholongwane.Kukho iindlela ezintathu eziphambili zeekhemikhali ze-1,3-dihydroxyacetone: i-electrocatalysis, i-metal catalytic oxidation, kunye ne-formaldehyde condensation.Ukuveliswa kweekhemikhali ze-1,3-dihydroxyacetone kusekho kwinqanaba lophando lwebhubhoratri.Ukuveliswa kwe-1,3-dihydroxyacetone ngendlela ye-biological kunenzuzo ebalulekileyo: imveliso ephezulu yokuxininisa, izinga lokuguqulwa kwe-glycerol ephezulu kunye neendleko eziphantsi zokuvelisa.Ukuveliswa kwe-1,3-dihydroxyacetone e-china nakwamanye amazwe ikakhulukazi yamkela indlela yokuguqulwa kwe-microbial ye-glycerol.

Indlela yokwenziwa kweekhemikhali

1. I-1,3-dihydroxyacetone ixutywe ukusuka kwi-1,3-dichloroacetone kunye ne-ethylene glycol njengezona zixhobo eziphambili ngokukhusela i-carbonyl, i-etherification, i-hydrogenolysis, kunye ne-hydrolysis.I-1,3-dichloroacetone kunye ne-ethylene glycol zifudumala kwaye zixutywe kwi-toluene ukuvelisa i-2,2-dichloromethyl-1,3-dioxolane.Emva koko basabela nge-sodium benzylidene kwi-N, i-N-dimethylformamide ukuvelisa i-2,2-dibenzyloxy-1,3-dioxolane, ethi ke i-hydrogenated phantsi kwe-Pd / C catalysis ukuze idibanise i-1,3-dioxolane-2,2-dimethanol. ke i-hydrolyzed kwi-hydrochloric acid ukuvelisa i-1,3-dihydroxyacetone.Izinto eziluhlaza zokwenziwa kwe-1,3-dihydroxyacetone usebenzisa le ndlela kulula ukuyifumana, iimeko zokusabela zincinci, kwaye i-Pd / C catalyst inokuphinda isetyenziswe, enexabiso elibalulekileyo lesicelo.

2. I-1,3-dihydroxyacetone yenziwe kwi-1,3-dichloroacetone kunye ne-methanol ngokukhuselwa kwe-carbonyl, i-etherification, i-hydrolysis, kunye ne-hydrolysis reactions.I-1,3-dichloroacetone isabela nge-methanol engaphezulu kwe-anhydrous phambi kwe-absorbent ukuvelisa i-2,2-dimethoxy-1,3-dichloropropane, ethi ke ifudunyezwe nge-sodium benzylate kwi-N, i-N-dimethylformamide ukuvelisa i-2,2-dimethoxy. -1,3-dibenzyloxypropane.Emva koko i-hydrogenated phantsi kwe-Pd / C catalysis ukuvelisa i-2,2-dimethoxy-1,3-propanediol, ethi ke i-hydrolyzed kwi-hydrochloric acid ukuvelisa i-1,3-dihydroxyacetone.Le ndlela ithatha indawo yomkhuseli we-carbonyl ukusuka kwi-ethylene glycol ukuya kwi-methanol, okwenza kube lula ukuhlula kunye nokucoca imveliso ye-1,3-dihydroxyacetone, enophuhliso olubalulekileyo kunye nexabiso lesicelo.

3. Ukwenziwa kwe-1,3-dihydroxyacetone usebenzisa i-acetone, i-methanol, i-chlorine okanye i-bromine njengezona zinto ziphambili.I-acetone, i-anhydrous methanol, kunye negesi ye-chlorine okanye i-bromine isetyenziselwa ukuvelisa i-2,2-dimethoxy-1,3-dichloropropane okanye i-1,3-dibromo-2,2-dimethoxypropane ngenkqubo enye.Emva koko zi-etherified kunye ne-sodium benzylate ukuvelisa i-2,2-dimethoxy-1,3-dibenzyloxypropane, ethi ke i-hydrogenated kunye ne-hydrolyzed ukuvelisa i-1,3-dihydroxyacetone.Le ndlela ineemeko zokusabela kancinci, kwaye impendulo "yembiza enye" ​​inqanda ukusetyenziswa kwe-1,3-dichloroacetone ebiza kakhulu kwaye ecaphukisayo, iyenza ibenexabiso eliphantsi kwaye ixabiseke kakhulu kuphuhliso.

Usetyenziso

I-1,3-Dihydroxyacetone yi-ketose eyenzeka ngokwemvelo enokuchithwa kwezinto eziphilayo, ezidliwayo, kwaye ezingenayo ityhefu kumzimba womntu kunye nokusingqongileyo.Sisongezo esisebenza ngeendlela ezininzi esinokusetyenziswa kwimizi-mveliso yezithambiso, amayeza kunye nokutya.

Isetyenziswa kwishishini lezithambiso

I-1,3-Dihydroxyacetone isetyenziswa kakhulu njengesithako sefomula kwizinto zokuthambisa, ngakumbi njenge-sunscreen eneziphumo ezikhethekileyo, ezinokuthintela ukukhuphuka okugqithisileyo komswakama wesikhumba, kwaye idlale indima ekufumeni, ukukhuselwa kwelanga, kunye nokukhusela i-UV radiation.Ukongezelela, amaqela asebenzayo e-ketone kwi-DHA angasabela kunye ne-amino acids kunye namaqela e-amino ye-keratin yesikhumba ukwenza i-polymer emdaka, ebangela ukuba ulusu lwabantu luvelise umbala omdaka wokufakelwa.Ke ngoko, inokuphinda isetyenziswe njengesifaniso sokuvezwa lilanga ukufumana ulusu olumdaka okanye olumdaka olujongeka ngokufanayo nesiphumo sokuvezwa kwexesha elide ekukhanyeni kwelanga, kuyenza ibonakale intle.

Phucula ipesenti yenyama ebhityileyo yeehagu

I-1,3-Dihydroxyacetone yimveliso ephakathi ye-sugar metabolism, idlala indima ebalulekileyo kwinkqubo ye-sugar metabolism, ukunciphisa amafutha omzimba wehagu kunye nokuphucula ipesenti yenyama ephilileyo.Abasebenzi baseJapan bezenzululwazi kunye nezobuchwepheshe baye babonisa ngokusebenzisa iimvavanyo ukuba ukongeza inani elithile le-DHA kunye nomxube we-pyruvate (ityuwa ye-calcium) kwisondlo sehagu (kwi-3: 1 ubunzima bomlinganiselo) kunokunciphisa umthamo we-fat back meat nge-12% ukuya. I-15%, kunye nomxholo wamanqatha wenyama yomlenze kunye neyona nto ide kakhulu ye-back muscle nayo iyancipha ngokuhambelanayo, kunye nokwanda kweprotheni.

Ukutya okusebenzayo

Ukongezwa kwe-1,3-dihydroxyacetone (ingakumbi ngokudibanisa ne-pyruvate) kunokuphucula izinga le-metabolism yomzimba kunye ne-fatty acid oxidation, enokuthi itshise ngokufanelekileyo amanqatha ukunciphisa amafutha omzimba kunye nokulibazisa ukufumana ubunzima (impembelelo yokunciphisa umzimba), kunye nokunciphisa izinga lokunyuka izifo ezinxulumeneyo.Isenokuphucula uvakalelo lwe-insulin kunye nokunciphisa inqanaba le-cholesterol yeplasma ebangelwa kukutya okuphezulu kwe-cholesterol.Ukuxhaswa kwexesha elide kunokunyusa izinga lokusetyenziswa kweswekile yegazi kunye nokugcina i-muscle glycogen, Kubadlali bezemidlalo, kunokuphucula ukusebenza kwabo kokunyamezela kwe-aerobic.

Okunye ukusetyenziswa

I-1,3-dihydroxyacetone ingasetyenziswa ngokuthe ngqo njenge-antiviral reagent.Ngokomzekelo, kwinkcubeko yenkukhu ye-embryo, ukusetyenziswa kwe-DHA kunokuthintela kakhulu usulelo lwe-chicken distemper virus, ukubulala i-51% ukuya kwi-100% yentsholongwane.Kwishishini lesikhumba, i-DHA ingasetyenziswa njenge-arhente ekhuselayo kwiimveliso zesikhumba.Ukongeza, izithinteli ikakhulu ezenziwe nge-DHA zinokusetyenziselwa ukugcinwa kunye nokugcinwa kweziqhamo kunye nemifuno, iimveliso zasemanzini, kunye neemveliso zenyama.